It all started in 1999 following a presentation by Bob Chen. In his talk, he stressed the need to improve vaccine safety monitoring by developing internationally accepted standards.

Among the members of the enthralled audience were Harald Heijbel, Ulrich Heininger, Tom Jefferson, and Elisabeth Loupi. After the talk they excitedly approached Bob Chen. The five of them decided to start a project to develop a common language and standardized research methodology to improve the accuracy of vaccine safety risk assessment.

Thus, the Brighton Collaboration was formed. Since then we have become a global resource for vaccine safety. Here is a chronological list of our milestones:

Brighton Collaboration Milestones

YEAR

MILESTONES

2014

Report on drivers of public concern around Pentavalent Vaccine and SIDS in Southern India available

2014

Report on pattern of spontaneous reports on narcolepsy and H1N1 vaccine and applicability of Brighton Collaboration case definition and automated classification tool available

2013

Clinical Advisory Forum of Experts (CAFÉ) created

2013

Reference set of positive and negative associations between vaccines and adverse events created for performance testing of signal detection methods

2013

Publication of narcolepsy incidence rates in Europe (VAESCO)

2013

Templates for Sendai and vesicular stomatitis viral vector

2013

Publication of global study investigating Guillain-Barré Syndrome following 2009 H1N1 pandemic influenza vaccine

2013

Global H1N1 Narcolepsy case control study (SOMNIA) expanded to include AS03 and MF59 adjuvanted 2009 H1N1 pandemic influenza vaccine

2013

Global inventory of electronic health care database comprising pediatric data is launched (GRiP)

2013

Narcolepsy case definition published

2013

First online BC Journal Club established

2013

Roadmap for the international collaborative epidemiologic monitoring of safety and effectiveness of new high priority vaccines published in the journal Vaccine

2013

Brighton Collaboration Foundation is partner in European Medical Information Framework (EMIF) project. Research Grant -Innovative Medicines Initiative (IMI)

2012

Vaccine Safety Quarterly (VSQ) newsletter launched

2012

VACCINE.GRID is established by the Brighton Collaboration Foundation as an independent public charity meeting the needs of public-private interaction.

2012

Template for safety section of vaccine clinical trial protocols 

2012

Third set of  6 case definitions published in the Journal Vaccine (2007-2012)

2012

Publications from  multi-country vaccine outcome studies become available

2012

Brighton Collaboration Foundation in first GVSI projects

2012

First Global Vaccine Safety Update Symposium in association with the Vaccine and GVSI Congress

2012

Brighton Collaboration Foundation signs contract with CDC to conduct global narcolepsy study (SOMNIA)

2011

The network comprises 3123 participants from 124 countries

2011

The first regional chapter of the Collaboration is founded in the US. The Brighton Foundation US is registered as a 501(c)(3) public charity in Massachusetts.

2011

Launch of Vaccine Safety Ontology Group

2011

Brighton Collaboration Foundation is Planning Group member of the Global Vaccine Safety Initiative (GVSI) coordinated by WHO

2011

Interim narcolepsy case definition available

2011

Template ready for yellow fever vaccine viral vector

2011

Publication of European study investigating Guillain-Barré Syndrome following 2009 H1N1 pandemic influenza vaccine (VAESCO)

2011

Brighton Collaboration Foundation is partner in Global Research in Pediatrics (GRiP) project. Research Grant - European Commission, DG Research FP-7

2010

The network comprises 2413 participants from 112 countries

2010

Updated infrastructure to serve as a global vaccine safety resource

2010

First data on the risk of Guillain-Barré Syndrome as an AEFI of Pandemic Influenza (H1N1) vaccine

2009

General guidelines for collection, analysis and publication of vaccine safety data

2009

Brighton Collaboration Foundation signs project agreement with ECDC to build the European Vaccine Safety Data Network (VAESCO)

2009

The European Vaccine Safety Data Network comprises 9 countries involved covering a population of over 50 million

2009

Pioneering multi-country vaccine outcome studies based on health care record linkage

2009

CDC charges VAESCO to investigate 2009 H1N1 pandemic influenza vaccine safety

2009

First European incidence rates of adverse events of special interest reported to European authorities

2009

Gates Foundation project: Global Vaccine Safety Blueprint signed with WHO

2008

EMA recommends the use of Brighton Collaboration case definitions

2008

First formal evaluation of 6 case definitions in US Vaccine Adverse Event Reporting System (VAERS)

2008

Automatic case classification tool online

2007

Revised HHE definition published

2007

Second set of 16 case definitions published in journal Vaccine

2007

First formal evaluation of case definition in background incidence rate study

2007

FDA recommends the use of Brighton Collaboration case definitions

2006

First formal evaluation of HHE case definition in surveillance system (Netherlands) – modification recommended

2006

Brighton Collaboration is prominently referred to in the Redbook of the American Academy of Pediatrics

2006

The network comprises 863 participants from 72 countries. The world largest network of professionals concerned with vaccine safety

2005

UN Council for International Organization of Medical Sciences (CIOMS) endorses first case definitions and guideline documents

2004

First 6 case definitions with respective guidelines published in journal Vaccine

2004

The network comprises 535 participants from 59 countries

2003

Brighton Collaboration Foundation registered in Switzerland founded by the University Children's Hospital Basel (UKBB)

2002

The network comprises 315 participants from 40 countries

2002

Collaboration presented at 15 scientific meetings

2002

First publication on the Brighton Collaboration

2001

The first 6 Working Groups built to develop AEFI case definitions

2001

Partner in EUSAFEVAC project. Research grant - European Commission, DG Research FP-5

2001

First Official launch meeting of the “Brighton Collaboration”

2000

The World Health Organization (WHO) provides seeding funds

2000

Operations office established to realize the vision

1999

Inception of Brighton Collaboration by Founding members