This post contains the Companion Guide for Anaphylaxis. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They contain resources and tools specific to events that have a published Brighton Collaboration case definition. The resources include risk factors and background rates for the event as well as a summary of key caveats from the case definition to:

1) guide real time investigations needed to meet the case definition as well as to look for diseases that would exclude the event as a case; and 2) guidelines for analysis and presentation of the event as an adverse event of special interest (AESI). The tools include a detailed case report form that guides the abstraction and interpretation of key data from medical records needed to meet case definition criteria as well as two different abbreviated one page formats for summarizing data on the case definition criteria and algorithms to assign the level of certainty.


Click here to access the revised case definition

Click here to access the 2007 version of the case definition 

Companion Guide

Click here to view the Companion Guide

This deliverable replaces an earlier version of the Anaphylaxis Companion Guide (completed Feb 5, 2021) which accompanied the 2007 Anaphylaxis case definition.  A new Working Group was formed in 2021 to review and revise the 2007 Anaphylaxis case definition (Anaphylaxis V-1) due to identified issues of the V-1 definition over-calling events with allergic symptoms as anaphylaxis. The new V-2 case definition was completed in September 2022, and this Companion Guide updates the previous one primarily as regards the tools for data abstraction and application to determine level of certainty.  No changes were needed for the other sections including risk factors, background rates and ICD9/10-CM & MedDRA codes. This guide should replace the earlier version and can be used by stakeholders to assess the occurrence of anaphylaxis in several settings including as an adverse event following immunization.


More Case Definitions