On behalf of the Brighton Collaboration Autoimmune Hepatitis Case Definition Working Group, please find below a manuscript on “Autoimmune hepatitis: Brighton Collaboration case definition and guidelines for data collection, analysis, and presentation of immunisation safety data”.
It has been developed on an expedited basis as autoimmune hepatitis is an adverse event of special interest. There have been reports of autoimmune hepatitis developing following COVID-19 infection, including in unvaccinated patients.
The Working Group has members with significant clinical (adult and paediatric hepatologists with expertise in autoimmune hepatitis), vaccine safety, pharmacovigilance, and vaccine regulatory expertise from regulatory bodies, public health authorities, academia, and consulting from high and low- and middle-income countries.
The draft CD has undergone external review, including from Ethiopian, Malawian, Ugandan and Chilean investigators and the useful feedback received was discussed and incorporated in the document.
Please share your feedback by end of day Oct 16, 2023, if feasible.
Dr Sonali Kochhar and Prof John M. Vierling
Dr Sonali Kochhar, MD
Clinical Associate Professor
Department of Global Health
University of Washington, Seattle
John M. Vierling, MD, FACP, FAASLD. AGAF
Professor of Medicine and Surgery
Chief of Hepatology
Director of Baylor Liver Health
Director of Advanced Liver Therapies
Section of Gastroenterology and Hepatology
Margaret M. and Albert B. Alkek Department of Medicine
Baylor College of Medicine
Division of Abdominal Transplantation
Michael E. DeBakey Department of Surgery