Chikungunya

Priority List of Adverse events of special interest for

Chikungunya

AESI: Myocarditis / Pericarditis
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Thrombosis / Thromboembolism
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Hemorrhagic disease
Specific to Chikungunya disease: ✅
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023


AESI: Thrombocytopenic Thrombosis Syndrome ²
Specific to vaccine: Adeno vectors
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

AESI: Anaphylaxis
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Thrombocytopenia
Specific to Chikungunya disease: ✅
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Dec 2023


AESI: Acute/chronic Inflammatory Rheumatism
Specific to Chikungunya disease: ✅
Brighton Case Definition:Prioritized, date TBD
Brighton CD Companion Guide:Prioritized, date TBD

AESI: Generalized convulsion
Specific to Chikungunya disease: ✅
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Aseptic meningitis
Specific to Chikungunya disease: ✅
Specific to vaccine: Live attenuated viral vaccine​
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Acute Disseminated Encephalomyelitis
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Encephalitis
Specific to Chikungunya disease: ✅
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Myelitis
Specific to Chikungunya disease: ✅
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Guillain Barré Syndrome
Specific to Chikungunya disease: ✅
Specific to vaccine: Some vaccines¹
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Bell’s Palsy
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Uveitis/Retinitis/Optic neuritis
Specific to Chikungunya disease: ✅
Brighton Case Definition:Prioritized, date TBD
Brighton CD Companion Guide:Prioritized, date TBD

AESI: Alopecia
Specific to Chikungunya disease: ✅
Brighton Case Definition: TBD
Brighton CD Companion Guide: TBD

AESI: Spontaneous abortion
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023


AESI: Stillbirth
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Aug 2023


AESI: Maternal death
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Aug 2023


AESI: Neonatal sepsis
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD


AESI: Neonatal encephalopathy
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD


AESI: Neurodevelopmental delay
Specific to Chikungunya disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD

1 Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.

Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to Chikungunya vaccine trials HERE.

SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:

COVID-19
Chikungunya
Lassa Fever
Rift Valley Fever
COVID-19
Chikungunya
Lassa Fever
Rift Valley Fever