Lassa Fever

Priority List of Adverse events of special interest for

Lassa Fever

AESI: Pericarditis
Specific to LF disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Hemorrhagic disease
Specific to LF disease: ✅
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023


AESI: Thrombocytopenic Thrombosis Syndrome
Specific to vaccine: ChAdOx1 Ad26
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023


AESI: Capillary Leak Syndrome
Specific to LF disease: ✅
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023


AESI: Anaphylaxis
Specific to LF disease: ✅
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Thrombocytopenia
Specific to LF disease: ✅
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: End of 2023

AESI: Generalized convulsion
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Aseptic meningitis
Specific to LF disease: ✅
Specific to vaccine: Live attenuated viral vaccine​
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Encephalitis
Specific to LF disease: ✅
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Myelitis
Specific to LF disease: ✅
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Sensorial Hearing Loss
Specific to LF disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access


AESI: Guillain Barré Syndrome
Specific to vaccine: Some vaccines¹
Brighton CD Companion Guide: TBD

AESI: Alopecia
Specific to LF disease: ✅
Brighton Case Definition: TBD
Brighton CD Companion Guide: TBD

AESI: Spontaneous abortion
Specific to LF disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023


AESI: Stillbirth
Specific to LF disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023


AESI: Maternal death
Specific to LF disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD


AESI: Neonatal death
Specific to LF disease: ✅
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD

1 Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.

Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to Lassa Fever vaccine trials HERE.

SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:

COVID-19
Chikungunya
Lassa Fever
Rift Valley Fever
COVID-19
Chikungunya
Lassa Fever
Rift Valley Fever