We build trust in the safety of vaccines through rigorous science.
Case Definitions
This deliverable collates into a single document the SPEAC Spontaneous Abortion and Ectopic Pregnancy resources, including the ICD9/10-CM, MedDRA and SNOMED codes, background[...]
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This document includes a Brighton Collaboration case definition of the term “Sensorineural Hearing Loss” (SNHL) as well as guidelines for data collection, analysis,[...]
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This post contains the Companion Guide for Preterm Birth and Assessment of Gestational Age. This and other companion guides have been created as[...]
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This is a Brighton Collaboration case definition of the term “Vaccine-associated Enhanced Disease” (VAED) to be utilized in the evaluation of adverse events[...]
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This post contains the Companion Guide for Thrombosis and Thromboembolism. This and other companion guides have been created as part of the CEPI-funded SPEAC project.[...]
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This is a revision of the Brighton Collaboration Case Definition of the term “Anaphylaxis” to be utilized in the evaluation of adverse events[...]
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This is a Brighton Collaboration Case Definition of the term “Myocarditis” and “Pericarditis” to be utilized in the evaluation of adverse events following[...]
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Since February 2021, multiple countries have reported cases of Thrombosis with Thrombocytopenia Syndrome (TTS) in persons who received the COVID-19 vaccine. To further[...]
This post contains the Companion Guide for Generalized Convulsion. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They[...]
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This post contains the Companion Guide for Anaphylaxis. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They contain[...]
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This post contains the Companion Guide for Facial Nerve Palsy. This and other companion guides have been created as part of the CEPI-funded SPEAC project.[...]
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This post contains the Companion Guide for Acute Disseminated Encephalomyelitis (ADEM). This and other companion guides have been created as part of the CEPI-funded SPEAC[...]
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This post contains the Companion Guide for Acute Encephalitis. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They[...]
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This post contains the Companion Guide for Thrombocytopenia. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They contain[...]
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This post contains the Companion Guide for Aseptic Meningitis. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They[...]
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This post contains the Companion Guide for Guillain Barré and Miller Fisher Syndromes. This and other companion guides have been created as part[...]
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This is a The Brighton Collaboration Case Definition of the term “Acute Respiratory Distress Syndrome (ARDS)” to be utilized in the evaluation of[...]
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This is a Brighton Collaboration Case Definition of the terms “Multisystem Inflammatory Syndrome in Children (MIS-C)” and “Multisystem Inflammatory Syndrome in Adults (MIS-A)”[...]
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This post contains the Companion Guide for Acute Myelitis. This and other companion guides have been created as part of the CEPI-funded SPEAC project. They[...]
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Need for developing a case definition and guidelines for data collection, analysis, and presentation of wheeze as an adverse event following immunization Wheeze[...]
Vaccine Safety Templates
Several live-attenuated viral vaccine candidates are among the COVID-19 vaccines in development. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) has[...]
Many of the vaccines under development for COVID-19 involve the use of viral vectors. The Brighton Collaboration Benefit-Risk Assessment of Vaccines by Technology[...]
Replication-incompetent adenoviral vectors have been under investigation as a platform to carry a variety of transgenes, and express them as a basis for vaccine development.[...]
The Modified Vaccinia Ankara (MVA) vector system is being explored as a platform for development of multiple vaccines. This paper reviews the molecular and biological[...]
This paper uses a BRAVATO protein template to review the features of Medigen’s recombinant SARS-CoV-2 spike protein in prefusion stabilized form used to[...]
The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform[...]
This paper uses the BRAVATO inactivated virus vaccine template to review the features of an inactivated whole chikungunya virus (CHIKV) vaccine that has been evaluated in several preclinical[...]
This paper uses a BRAVATO nucleic acid template to review the features of Moderna’s rapid-response proprietary vaccine platform based on an mRNA delivery[...]
Auro Vaccines LLC has developed a protein vaccine to prevent disease from Nipah and Hendra virus infection that employs a recombinant soluble Hendra glycoprotein (HeV-sG) adjuvanted with aluminum[...]
Several inactivated viral vaccine candidates are among the COVID-19 vaccines in development. The Brighton Collaboration (BC) Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO), as[...]
Several protein vaccine candidates are among the COVID-19 vaccines in development. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) has prepared[...]
Nucleic acid (DNA and RNA) vaccines are among the most advanced vaccines for COVID-19 under development. The Brighton Collaboration Viral Vector Vaccines Safety Working[...]
This tool was aimed at identifying potential major hurdles or gaps that would need to be addressed during the development of vectored vaccines.[...]
In this paper, we use a standardized template describing key characteristics of the novel rVSV vaccine vectors, in comparison to wild type VSV. The template[...]
In this paper, we use a standardized template describing the key characteristics of the novel flavivirus vaccine vectors, in comparison to the parental[...]
News
This editorial by Dr. Robert T. Chen first appeared in the October 2023 issue of Safety by Numbers. It is reposted here with permission from[...]
Dear Brighton Collaboration members: Please find below a draft Brighton Collaboration case definition for both TTS (thrombosis and thrombocytopenia syndrome) and VITT (vaccine-induced[...]
This editorial was previously published in Vaccine Safety Quarterly. Karina Top, MD, MS Karina Top, MD, MS | Principal Investigator,[...]
On behalf of the Brighton Collaboration Autoimmune Hepatitis Case Definition Working Group, please find below a manuscript on “Autoimmune hepatitis: Brighton Collaboration case[...]
On behalf of the Brighton Collaboration BRAVATO (Benefit-Risk Assessment of VAccines by TechnolOgy) Working Group, please find enclosed a manuscript and accompanying case[...]
On 8 and 9 November 2022, the Maternal Immunization Working Group (MIWG) held an in-person and online hybrid meeting. The objectives of the[...]
We are updating the Brighton website and need help from frequent users to advance requirements and provide design feedback. We will do this work[...]
The Coalition for Epidemic Preparedness Innovations (CEPI) and the Brighton Collaboration, based in Atlanta at The Task Force for Global Health, announced the expansion of[...]
SPEAC has completed a fifth update to the Priority List of potential Adverse events of special interest relevant to COVID-19 vaccine trials. Past[...]
We are proud to announce that Dr. Bob Chen, Scientific Director of the Brighton Collaboration, received a special award for “Contributions to Public Health[...]
To help meet its increasing needs, the Secretariat for the Brighton Collaboration (BC) has recently posted a new staff position: Director of Research. The position[...]
Coalition for Epidemic Preparedness Innovations (CEPI) through the Safety Platform for Emergency vACcines (SPEAC) project, has funded the development of a training program for potential[...]
On behalf of the COVAX Vaccine Safety Working group: After COVID-19 vaccines are introduced into countries, it will be vital to generate real-world[...]
The current Brighton Collaboration Science Board has voted to accept all 16 candidates onto the new Brighton Collaboration Science Board. After consideration of[...]
SPEAC has completed a 4th update of the COVID-19 clinical literature covering the period from November 2020 – August 2021. Click HERE to[...]
We would like to announce the upcoming Brighton Collaboration Science Board election. The Science Board meets monthly for one hour to help determine[...]
As part of its role to support the assessment of safety of vaccines being evaluated in CEPI funded clinical trials, the Safety Platform[...]
Recent news of the possible complications of blood clots – or Thrombosis with Thrombocytopenia Syndrome (TTS) – following the AstraZeneca/Oxford and Johnson &[...]
The Benefit-Risk Assessment of Vaccines by TechnolOgy (BRAVATO) working group has developed standardized templates for the collection of key information for the development, efficacy, and[...]
The Centers for Disease Control and Prevention (CDC) has invested in The Task Force for Global Health (TFGH) to help low and middle income counties[...]
SPEAC has completed a second update of the COVID-19 clinical literature covering the period of August 8 through November 13th 2020. Based on this[...]
